DDOST

Across TCGA patient cohorts, DDOST mutation is significantly associated with the RNA expression of many other genes, with 2,207 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDOST-associated genes across cancer lineages are RNU6-5P, TRAJ49, and AKR1B1P3. Each is linked with DDOST in more than 1 cancer types. Because this analysis shows association rather than direction, both DDOST-to-partner and partner-to-DDOST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-5P grouped by DDOST-low versus DDOST-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDOST→partner) and Y-score (partner→DDOST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-5P →	+0.769	+2.771	<.001	<.001	3	2
UCEC	TRAJ49 →	+0.785	+2.363	.001	.002	3	2
UCEC	AKR1B1P3 →	+0.247	+2.627	.004	.006	3	2
UCEC	RNU11-2P →	+0.669	+2.811	<.001	.004	3	2
UCEC	CPS1-IT1 →	+0.041	+3.063	.001	.007	3	1
UCEC	NSUN3 →	+0.572	+3.345	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,207 associations by consensus.

RNU6-5P by DDOST expression — UCEC

Explore this box plot interactively →