Across TCGA patient cohorts, DDO RNA expression is significantly associated with the protein abundance of many other proteins, with 15,524 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DDO-associated proteins across cancer lineages are PYCARD, ARHGAP18, and SAAL1. Each is linked with DDO in more than 5 cancer types. Because this analysis shows association rather than direction, both DDO-to-partner and partner-to-DDO results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DDO→partner) and Y-score (partner→DDO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PYCARD →	+0.586	+0.541	<.001	.003	3	6
GBM	ARHGAP18 →	+0.474	+0.594	<.001	<.001	3	5
UCEC	SAAL1 →	-0.383	-1.100	<.001	<.001	3	5
GBM	SSRP1 →	-0.617	-0.609	<.001	<.001	3	5
GBM	SSRP1_S444 →	-0.410	-0.546	<.001	.001	3	5
GBM	SUPT16H →	-0.584	-0.576	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,524 associations by consensus.

Exploration

DDO survival (RNA) · tumor vs normal (RNA) · all DDO data types