DDN

Across TCGA cell cohorts, DDN mutation is significantly associated with the RNA expression of many other genes, with 107 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDN-associated genes across cancer lineages are HOXB1, SLC10A2, and C5orf52. Each is linked with DDN in more than 1 cancer types. Because this analysis shows association rather than direction, both DDN-to-partner and partner-to-DDN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HOXB1 grouped by DDN-low versus DDN-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDN→partner) and Y-score (partner→DDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HOXB1 →	+0.259	+3.632	.004	.009	3	1
STOMACH	SLC10A2 →	+0.861	+3.637	.004	.008	3	1
BLOOD_Leukemia	C5orf52 →	+0.022	+4.984	<.001	.002	3	1
OVARY	GLP1R →	+0.125	+3.063	<.001	.002	3	1
OVARY	SNTG2 →	+0.211	+3.844	.002	.001	3	1
OVARY	KCNA3 →	+0.026	+3.844	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 107 associations by consensus.

HOXB1 by DDN expression — STOMACH

Explore this box plot interactively →