DDN-AS1

Across TCGA pan-cancer cohorts, DDN-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated DDN-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DDN-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DDN-AS1 expression acts as an unfavorable survival marker, although some lineages such as READ and HNSC show a favorable association.

KIRC, ACC, and KICH are the cancer types where DDN-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	IV	0.397	0.747	<.001	140	view →
ACC	DFS	Median	All	0.231	0.647	<.001	117	view →
KICH	DFS	Quartile	All	0.477	1.000	<.001	110	view →
MESO	OS	Tertile	All	0.253	0.565	<.001	109	view →
LIHC	DFS	Median	All	0.210	0.354	<.001	68	view →
UVM	DFS	Median	III,IV	0.245	0.786	<.001	60	view →
CESC	DFS	Median	All	0.759	0.882	<.001	48	view →
BLCA	DFS	Tertile	All	0.258	0.590	.001	42	view →
LGG	OS	Tertile	All	0.737	0.881	<.001	33	view →
THCA	DFS	Quartile	II,III,IV	0.305	0.700	.005	31	view →
KIRP	DFS	Median	All	0.551	0.658	.006	20	view →
PRAD	OS	Quartile	All	0.780	0.940	.018	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

DDN-AS1–KIRC (DFS)

Open the KIRC breakdown →