DDN-AS1

Across TCGA pan-cancer cohorts, DDN-AS1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of DDN-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DDN-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DDN-AS1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where DDN-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DDN-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.568	<.001	12	view →
COAD	Male	II,III,IV	+1.094	<.001	11	view →
BLCA	All	All	+0.747	<.001	11	view →
LUAD	Male	II,III,IV	+0.990	<.001	9	view →
LIHC	All	All	+0.160	<.001	8	view →
LUSC	Male	II,III,IV	+0.621	<.001	7	view →
UCEC	All	All	+0.389	<.001	6	view →
CHOL	All	All	+0.746	<.001	5	view →
KIRP	All	III,IV	+0.248	.025	5	view →
BRCA	All	II,III,IV	+0.132	.007	4	view →
STAD	Male	All	+0.204	.005	3	view →
READ	All	All	+0.928	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

DDN-AS1–HNSC

Open the HNSC breakdown →