DDIT3

Across TCGA patient cohorts, DDIT3 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,535 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DDIT3-associated proteins across cancer lineages are PGRMC2_S104, SHMT2, and XPOT. Each is linked with DDIT3 in more than 4 cancer types. Because this analysis shows association rather than direction, both DDIT3-to-partner and partner-to-DDIT3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DDIT3 versus PGRMC2_S104 in LUAD, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DDIT3→partner) and Y-score (partner→DDIT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PGRMC2_S104 →	+0.980	+0.674	<.001	<.001	3	5
LSCC	SHMT2 →	+0.509	+0.750	<.001	<.001	3	4
CCRCC	XPOT →	+0.422	+0.652	<.001	<.001	3	4
LUAD	SNX6_S55 →	+0.824	+0.616	.001	.008	3	4
LUAD	FOXK1_S223 →	+0.760	+0.645	.006	<.001	3	4
GBM	PPP2R2D →	-0.323	-0.624	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,535 associations by consensus.

DDIT3 vs PGRMC2_S104 — LUAD

Explore this scatter interactively →