DDIT3

Across TCGA pan-cancer cohorts, DDIT3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated DDIT3 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DDIT3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DDIT3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LUAD show a favorable association.

KIRC, ESCA, and MESO are the cancer types where DDIT3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	III,IV	0.514	0.702	.001	94	view →
ESCA	DFS	Quartile	III,IV	0.212	0.642	<.001	63	view →
MESO	DFS	Quartile	All	0.217	0.505	<.001	58	view →
UVM	DFS	Median	All	0.266	0.931	.001	55	view →
KICH	OS	Median	III,IV	0.398	1.000	.003	46	view →
LIHC	OS	Quartile	All	0.599	0.805	<.001	39	view →
KIRP	DFS	Tertile	II,III,IV	0.335	0.704	.008	35	view →
COAD	DFS	Quartile	IV	0.367	0.744	<.001	34	view →
LUSC	DFS	Tertile	III,IV	0.319	0.632	.003	26	view →
BRCA	OS	Tertile	All	0.955	0.978	.005	23	view →
LGG	OS	Quartile	All	0.734	0.897	.003	20	view →
ACC	DFS	Tertile	All	0.187	0.761	.006	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

DDIT3–KIRC (DFS)

Open the KIRC breakdown →