DDIT3

Across TCGA cell cohorts, DDIT3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,462 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DDIT3-associated GO terms across cancer lineages are Blood vessel maturation, Negative regulation of interleukin-4 production, and PERK-mediated unfolded protein response. Each is linked with DDIT3 in more than 19 cancer types. Because this analysis shows association rather than direction, both DDIT3-to-partner and partner-to-DDIT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Blood vessel maturation grouped by DDIT3-low versus DDIT3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDIT3→partner) and Y-score (partner→DDIT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Blood vessel maturation →	+0.721	+1.988	.002	<.001	3	20
URINARY_TRACT	Negative regulation of interleukin-4 production →	+0.870	+2.664	.002	<.001	3	20
BLOOD_Myeloma	PERK-mediated unfolded protein response →	+0.165	+1.743	<.001	<.001	3	20
BLOOD_Myeloma	ATF6-mediated unfolded protein response →	+0.143	+1.848	.004	<.001	3	18
BONE	Regulation of determination of dorsal identity →	+0.273	+1.596	<.001	<.001	3	15
BONE	Negative regulation of translation in response to endoplasmic reticulum stress →	+0.195	+1.966	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,462 associations by consensus.

Blood vessel maturation by DDIT3 expression — STOMACH

Explore this box plot interactively →