Across TCGA pan-cancer cohorts, DDI2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DDI2 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DDI2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DDI2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and STAD are the cancer types where DDI2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.416	0.770	.008	12	view →
UCEC	DFS	Median	All	1.000	0.631	.036	4	view →
STAD	DFS	Median	III,IV	0.149	0.606	.004	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: DDI2 tumor-vs-normal RNA expression · all DDI2 data types