Across TCGA patient cohorts, DDI2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,116 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible DDI2-associated genes across cancer lineages are HBB, HBA2, and HBA1. Each is linked with DDI2 in more than 6 cancer types. Because this analysis shows association rather than direction, both DDI2-to-partner and partner-to-DDI2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDI2→partner) and Y-score (partner→DDI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HBB →	+1.836	+0.509	<.001	<.001	3	7
GBM	HBA2 →	+1.927	+0.544	<.001	<.001	3	6
GBM	HBA1 →	+1.800	+0.507	<.001	<.001	3	6
OV	LZIC →	+0.455	+0.299	.001	.003	3	4
CCRCC	HEMGN →	+0.515	+0.337	<.001	<.001	3	4
CCRCC	SLC4A1 →	+0.493	+0.274	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,116 associations by consensus.

Exploration

DDI2 survival (RNA) · tumor vs normal (RNA) · all DDI2 data types