Across TCGA patient cohorts, DDI2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDI2-associated genes across cancer lineages are EGFR_pY1068, Acetyl-a-Tubulin-Lys40, and Notch1. Each is linked with DDI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDI2-to-partner and partner-to-DDI2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDI2→partner) and Y-score (partner→DDI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.251	-2.321	.046	.035	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.518	+3.459	.042	.005	3	1
UCEC	Notch1 →	+0.238	+3.459	<.001	.005	3	1
UCEC	Annexin-1 →	+0.823	+3.019	.001	.019	3	1
UCEC	Chk1_pS345 →	-0.136	-3.000	.049	.036	3	1
UCEC	C-Raf →	+0.207	+2.321	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

DDI2 survival (RNA) · tumor vs normal (RNA) · all DDI2 data types