DDHD2

Across TCGA pan-cancer cohorts, DDHD2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DDHD2 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DDHD2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DDHD2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where DDHD2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	II,III,IV	0.589	0.903	.010	23	view →
LUAD	DFS	Tertile	All	1.000	0.587	.005	14	view →
CCRCC	DFS	Quartile	All	0.819	0.586	.029	4	view →
LSCC	OS	Quartile	III,IV	0.470	0.910	.024	2	view →
HNSC	DFS	Tertile	IV	0.840	0.593	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DDHD2–PDAC (DFS)

Open the PDAC breakdown →