DDHD2

Across TCGA patient cohorts, DDHD2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDHD2-associated genes across cancer lineages are MEK1, FoxM1, and INPP4B. Each is linked with DDHD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDHD2-to-partner and partner-to-DDHD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by DDHD2-low versus DDHD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDHD2→partner) and Y-score (partner→DDHD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.407	+2.807	.010	.003	3	2
UCEC	FoxM1 →	+0.239	+3.331	.034	.005	3	1
UCEC	INPP4B →	-0.389	-3.459	.005	.005	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.463	-3.000	.018	.036	3	1
UCEC	Rad50 →	-0.267	-2.115	.011	.019	3	1
UCEC	Rictor_pT1135 →	-0.094	-3.000	.036	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MEK1 by DDHD2 expression — UCEC

Explore this box plot interactively →