DDHD2

Across TCGA cell cohorts, DDHD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,045 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDHD2-associated GO terms across cancer lineages are Cytoskeleton-dependent cytokinesis, Cytokinesis, and Negative regulation of sister chromatid cohesion. Each is linked with DDHD2 in more than 14 cancer types. Because this analysis shows association rather than direction, both DDHD2-to-partner and partner-to-DDHD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoskeleton-dependent cytokinesis grouped by DDHD2-low versus DDHD2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDHD2→partner) and Y-score (partner→DDHD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Cytoskeleton-dependent cytokinesis →	+0.081	+0.904	<.001	.005	3	15
LUNG_SCLC	Cytokinesis →	+0.077	+0.946	<.001	.003	3	15
LUNG_NSCLC_LUSC	Negative regulation of sister chromatid cohesion →	+0.162	+1.554	.002	.002	3	14
UPPER_AERODIGESTIVE_TRACT	Interkinetic nuclear migration →	+0.133	+1.298	<.001	<.001	3	14
LARGE_INTESTINE	Positive regulation of cilium assembly →	+0.079	+1.159	<.001	<.001	3	14
URINARY_TRACT	DNA biosynthetic process →	+0.063	+1.175	.001	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,045 associations by consensus.

Cytoskeleton-dependent cytokinesis by DDHD2 expression — LUNG_SCLC

Explore this box plot interactively →