DDHD1

Across TCGA patient cohorts, DDHD1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDHD1-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and eEF2. Each is linked with DDHD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDHD1-to-partner and partner-to-DDHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by DDHD1-low versus DDHD1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDHD1→partner) and Y-score (partner→DDHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PCNA →	+0.241	+3.000	.029	.036	3	3
UCEC	Caspase-7-cleavedD198 →	+0.615	+2.242	.001	.005	3	3
UCEC	eEF2 →	+0.313	+1.392	.007	.019	3	2
UCEC	MEK1 →	+0.367	+3.700	.002	.001	3	2
UCEC	mTOR_pS2448 →	-0.130	-1.652	.008	.006	3	2
UCEC	p27_pT198 →	+0.088	+2.087	.013	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

PCNA by DDHD1 expression — SKCM

Explore this box plot interactively →