DDHD1

Across TCGA pan-cancer cohorts, DDHD1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of DDHD1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DDHD1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DDHD1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where DDHD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DDHD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.079	<.001	12	view →
KIRC	Male	All	+0.481	<.001	9	view →
KIRP	All	All	+0.445	<.001	7	view →
LIHC	Female	II,III,IV	+0.564	<.001	6	view →
LUAD	Female	II,III,IV	−0.513	.001	5	view →
STAD	All	II,III,IV	+0.589	.003	4	view →
COAD	All	II,III,IV	+0.253	.006	4	view →
CHOL	Male	All	+1.033	<.001	3	view →
LUSC	Male	All	−0.251	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

DDHD1–HNSC

Open the HNSC breakdown →