DDHD1

Across TCGA cell cohorts, DDHD1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible DDHD1-associated genes across cancer lineages are FSHB, RNF186, and SPATA31D3. Each is linked with DDHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDHD1-to-partner and partner-to-DDHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FSHB grouped by DDHD1-low versus DDHD1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDHD1→partner) and Y-score (partner→DDHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FSHB →	+0.008	+4.247	<.001	.004	3	1
BLOOD_Lymphoma	RNF186 →	+0.344	+3.321	<.001	.006	3	1
STOMACH	SPATA31D3 →	+0.010	+4.285	<.001	.007	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
BREAST	CCL23 →	+0.044	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FSHB by DDHD1 expression — BLOOD_Lymphoma

Explore this box plot interactively →