DDC

Across TCGA patient cohorts, DDC RNA expression is significantly associated with the protein abundance of many other proteins, with 9,288 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible DDC-associated proteins across cancer lineages are VIL1, CASP4, and DPYD. Each is linked with DDC in more than 4 cancer types. Because this analysis shows association rather than direction, both DDC-to-partner and partner-to-DDC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DDC versus VIL1 in UCEC, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DDC→partner) and Y-score (partner→DDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VIL1 →	+1.628	+1.012	<.001	.006	3	5
HNSC	CASP4 →	-0.549	-0.502	<.001	.009	3	4
LUAD	DPYD →	-0.509	-1.269	<.001	<.001	3	4
HNSC	HOMER3 →	-0.366	-0.722	<.001	.009	3	4
PDAC	MMP14 →	-0.420	-1.113	<.001	<.001	3	4
LUAD	AOC1 →	+1.033	+1.710	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,288 associations by consensus.

DDC vs VIL1 — UCEC

Explore this scatter interactively →