DDB1

Across TCGA patient cohorts, DDB1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,599 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DDB1-associated genes across cancer lineages are TKFC, HSD17B8, and MKS1. Each is linked with DDB1 in more than 6 cancer types. Because this analysis shows association rather than direction, both DDB1-to-partner and partner-to-DDB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DDB1 versus TKFC in BRCA, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDB1→partner) and Y-score (partner→DDB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TKFC →	+0.667	+0.212	<.001	<.001	3	7
UCEC	HSD17B8 →	+0.886	+0.094	<.001	.004	3	7
HNSC	MKS1 →	+0.477	+0.207	<.001	<.001	3	6
COAD	PLEK →	-0.952	-0.151	.007	.006	3	6
BRCA	BCL2A1 →	-1.044	-0.183	.004	.001	2	7
BRCA	FAM86C2P →	+0.480	+0.126	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,599 associations by consensus.

DDB1 vs TKFC — BRCA

Explore this scatter interactively →