DCX

Across TCGA patient cohorts, DCX mutation is significantly associated with the RNA expression of many other genes, with 4,887 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCX-associated genes across cancer lineages are PCAT19, TMEM104, and ACOT2. Each is linked with DCX in more than 2 cancer types. Because this analysis shows association rather than direction, both DCX-to-partner and partner-to-DCX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCAT19 grouped by DCX-low versus DCX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCX→partner) and Y-score (partner→DCX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCAT19 →	-0.704	-1.777	<.001	<.001	3	3
SKCM	TMEM104 →	+0.425	+2.515	<.001	<.001	3	3
SKCM	ACOT2 →	+0.420	+3.944	.001	<.001	3	3
COAD	FAM30B →	+0.168	+4.602	<.001	.003	3	3
UCEC	UGDH →	+0.525	+1.501	<.001	.006	3	3
UCEC	OSGIN1 →	+1.111	+2.368	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,887 associations by consensus.

PCAT19 by DCX expression — UCEC

Explore this box plot interactively →