DCX

Across TCGA pan-cancer cohorts, DCX RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DCX’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DCX RNA is repressed in tumor relative to normal tissue. In most cancer types DCX is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and BRCA are the cancer types where DCX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DCX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.037	<.001	8	view →
COAD	All	IV	−0.071	.002	7	view →
BRCA	Female	All	−0.679	<.001	6	view →
LIHC	All	All	+0.095	.015	5	view →
KIRC	Male	All	+0.099	.002	4	view →
HNSC	All	All	−0.119	.020	3	view →
KICH	All	All	−0.050	.010	3	view →
BLCA	All	IV	−0.127	.029	1	view →
ESCA	All	All	−0.099	.039	1	view →
LUAD	All	All	+0.016	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

DCX–THCA

Open the THCA breakdown →