DCX

Across TCGA patient cohorts, DCX mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCX-associated genes across cancer lineages are TFRC, eEF2, and GAPDH. Each is linked with DCX in more than 2 cancer types. Because this analysis shows association rather than direction, both DCX-to-partner and partner-to-DCX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by DCX-low versus DCX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCX→partner) and Y-score (partner→DCX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.412	+1.847	.005	.007	3	3
UCEC	eEF2 →	+0.271	+1.925	.006	.004	3	2
SKCM	GAPDH →	+0.438	+2.000	.028	.008	3	2
SKCM	IGFBP2 →	-0.369	-1.514	.034	.014	3	2
SKCM	PDCD4 →	-0.414	-1.807	.002	.004	3	2
SKCM	Bcl-xL →	+0.122	+1.919	.044	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

TFRC by DCX expression — UCEC

Explore this box plot interactively →