DCUN1D5

Across TCGA pan-cancer cohorts, DCUN1D5 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of DCUN1D5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DCUN1D5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DCUN1D5 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where DCUN1D5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DCUN1D5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.353	<.001	12	view →
COAD	Female	II,III,IV	+1.610	<.001	11	view →
KIRC	Male	All	+0.381	<.001	11	view →
BLCA	Male	III,IV	+1.165	<.001	10	view →
LIHC	Male	II,III,IV	+1.311	<.001	9	view →
LUAD	Male	II,III,IV	+1.031	<.001	9	view →
LUSC	Female	II,III,IV	+1.450	<.001	7	view →
UCEC	All	II,III,IV	+1.031	<.001	6	view →
STAD	Male	II,III,IV	+0.924	<.001	6	view →
BRCA	All	All	+0.565	<.001	6	view →
CHOL	Male	All	+2.065	<.001	5	view →
READ	All	All	+0.944	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

DCUN1D5–HNSC

Open the HNSC breakdown →