DCUN1D2

Across TCGA patient cohorts, DCUN1D2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCUN1D2-associated genes across cancer lineages are 14-3-3_beta, HER3, and Heregulin. Each is linked with DCUN1D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCUN1D2-to-partner and partner-to-DCUN1D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by DCUN1D2-low versus DCUN1D2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCUN1D2→partner) and Y-score (partner→DCUN1D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.129	-2.295	.007	.033	3	1
UCEC	HER3 →	-0.288	-2.990	.030	.036	3	1
UCEC	Heregulin →	-0.145	-3.169	.015	.019	3	1
UCEC	JNK2 →	+0.217	+2.817	.023	.036	3	1
UCEC	MEK1 →	+0.500	+3.321	.004	.010	3	1
UCEC	SF2 →	-0.157	-3.571	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

14-3-3_beta by DCUN1D2 expression — UCEC

Explore this box plot interactively →