DCTN6

Across TCGA patient cohorts, DCTN6 mutation is significantly associated with the RNA expression of many other genes, with 121 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCTN6-associated genes across cancer lineages are ACD, LINC00544, and WDFY4. Each is linked with DCTN6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCTN6-to-partner and partner-to-DCTN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACD grouped by DCTN6-low versus DCTN6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCTN6→partner) and Y-score (partner→DCTN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACD →	+0.513	+3.354	.009	.005	3	1
UCEC	LINC00544 →	+0.110	+2.431	.001	.007	3	1
UCEC	WDFY4 →	+0.590	+3.364	.004	.005	3	1
UCEC	DIAPH1 →	+0.641	+3.212	.003	.009	3	1
BRCA	RNA5SP24 →	+0.317	+7.731	<.001	.009	3	1
UCEC	SYVN1 →	+0.387	+3.343	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 121 associations by consensus.

ACD by DCTN6 expression — UCEC

Explore this box plot interactively →