DCTN6

Across TCGA pan-cancer cohorts, DCTN6 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DCTN6’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DCTN6 RNA is repressed in tumor relative to normal tissue. In most cancer types DCTN6 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where DCTN6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DCTN6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.354	<.001	8	view →
KIRC	All	All	+0.404	<.001	7	view →
KICH	Female	All	−0.929	<.001	6	view →
LUAD	Female	II,III,IV	−0.560	<.001	6	view →
HNSC	All	All	+0.286	.006	6	view →
BRCA	Female	All	−0.262	<.001	4	view →
CHOL	All	All	+1.527	<.001	3	view →
BLCA	All	IV	−0.621	.026	3	view →
PRAD	All	All	−0.302	.001	2	view →
LUSC	All	All	−0.282	.001	2	view →
READ	Female	All	−0.669	.028	1	view →
ESCA	All	All	+0.466	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DCTN6–THCA

Open the THCA breakdown →