DCTN6

Across TCGA cell cohorts, DCTN6 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,550 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DCTN6-associated GO terms across cancer lineages are Regulation of regulatory ncRNA-mediated heterochromatin formation, Negative regulation of regulatory ncRNA-mediated heterochromatin formation, and piRNA-mediated gene silencing by mRNA destabilization. Each is linked with DCTN6 in more than 10 cancer types. Because this analysis shows association rather than direction, both DCTN6-to-partner and partner-to-DCTN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of regulatory ncRNA-mediated heterochromatin formation grouped by DCTN6-low versus DCTN6-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DCTN6→partner) and Y-score (partner→DCTN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.117	+0.709	.004	<.001	3	11
STOMACH	Negative regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.117	+0.709	.004	<.001	3	11
OVARY	piRNA-mediated gene silencing by mRNA destabilization →	+0.229	+0.762	<.001	<.001	3	9
SOFT_TISSUE	Negative regulation of calcium ion import across plasma membrane →	+0.129	+0.370	<.001	.009	3	9
OVARY	Protein neddylation →	+0.074	+0.527	.003	<.001	2	10
SOFT_TISSUE	Multivesicular body assembly →	+0.083	+0.692	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,550 associations by consensus.

Regulation of regulatory ncRNA-mediated heterochromatin formation by DCTN6 expression — STOMACH

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