DCTN2

Across TCGA patient cohorts, DCTN2 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCTN2-associated genes across cancer lineages are A-Raf_pS299, MEK1, and BRCA2. Each is linked with DCTN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCTN2-to-partner and partner-to-DCTN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by DCTN2-low versus DCTN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCTN2→partner) and Y-score (partner→DCTN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.178	-3.000	.010	.036	3	1
UCEC	MEK1 →	+0.427	+3.000	.043	.036	3	1
UCEC	BRCA2 →	-0.178	-2.992	.015	.036	3	1
UCEC	Di-Ras3 →	-0.171	-3.000	.046	.037	3	1
UCEC	Rab25 →	-0.376	-3.000	.049	.037	2	1
UCEC	Tuberin →	+0.518	+3.000	<.001	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

A-Raf_pS299 by DCTN2 expression — UCEC

Explore this box plot interactively →