Across TCGA patient cohorts, DCTN1 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCTN1-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and 4E-BP1. Each is linked with DCTN1 in more than 4 cancer types. Because this analysis shows association rather than direction, both DCTN1-to-partner and partner-to-DCTN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCTN1→partner) and Y-score (partner→DCTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.063	+2.593	.001	.006	3	5
COAD	ATM →	-0.735	-3.459	<.001	.004	3	3
COAD	4E-BP1 →	+0.277	+3.459	.002	.005	3	3
UCEC	eIF4E →	+0.163	+1.807	.008	.003	3	2
COAD	INPP4B →	-0.483	-3.169	.001	.017	3	2
COAD	Lck →	+0.351	+2.610	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Exploration

DCTN1 survival (RNA) · tumor vs normal (RNA) · all DCTN1 data types