Across TCGA pan-cancer cohorts, DCTN1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DCTN1’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DCTN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DCTN1 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.
HNSC, LIHC, and THCA are the cancer types where DCTN1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DCTN1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.