DCTD

Across TCGA patient cohorts, DCTD mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCTD-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Src_pY416, and Src_pY527. Each is linked with DCTD in more than 1 cancer types. Because this analysis shows association rather than direction, both DCTD-to-partner and partner-to-DCTD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by DCTD-low versus DCTD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCTD→partner) and Y-score (partner→DCTD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.414	-2.459	.035	.019	3	2
UCEC	Src_pY416 →	-0.222	-2.794	.035	.003	3	2
UCEC	Src_pY527 →	-0.479	-3.311	.010	.010	3	2
UCEC	FoxM1 →	+0.267	+2.115	.018	.019	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.679	+2.999	.002	.035	3	1
UCEC	INPP4B →	-0.322	-3.169	.022	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

p38-MAPK_pT180_Y182 by DCTD expression — UCEC

Explore this box plot interactively →