DCTD

Across TCGA pan-cancer cohorts, DCTD RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of DCTD’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DCTD RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DCTD is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, THCA, and HNSC are the cancer types where DCTD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DCTD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+1.133	<.001	11	view →
THCA	All	IV	−1.007	<.001	11	view →
HNSC	All	III,IV	+0.680	<.001	10	view →
CHOL	All	All	+1.208	<.001	5	view →
LUAD	All	All	+0.252	<.001	5	view →
STAD	Male	II,III,IV	+0.740	<.001	4	view →
READ	All	All	+0.583	.015	2	view →
PRAD	All	All	+0.228	.007	2	view →
LUSC	All	All	+0.212	.008	2	view →
LIHC	Female	II,III,IV	+0.535	.031	1	view →
KICH	All	All	−0.370	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

DCTD–COAD

Open the COAD breakdown →