DCST2

Across TCGA patient cohorts, DCST2 mutation is significantly associated with the RNA expression of many other genes, with 1,868 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCST2-associated genes across cancer lineages are EIF3JP1, PRKAR1B-AS1, and RNA5SP93. Each is linked with DCST2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DCST2-to-partner and partner-to-DCST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF3JP1 grouped by DCST2-low versus DCST2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCST2→partner) and Y-score (partner→DCST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF3JP1 →	+0.189	+2.339	<.001	<.001	3	3
UCEC	PRKAR1B-AS1 →	+0.403	+3.639	.003	.001	3	3
SKCM	RNA5SP93 →	+0.072	+4.528	<.001	.003	3	2
UCEC	RN7SKP286 →	+0.045	+4.060	<.001	<.001	3	2
SKCM	LINC00428 →	+0.238	+1.921	.004	.009	3	2
SKCM	MAVS →	-0.559	-3.546	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,868 associations by consensus.

EIF3JP1 by DCST2 expression — UCEC

Explore this box plot interactively →