DCST1-AS1

Across TCGA pan-cancer cohorts, DCST1-AS1 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated DCST1-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DCST1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DCST1-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

KIRC, KICH, and UCEC are the cancer types where DCST1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.552	0.693	<.001	120	view →
KICH	OS	Median	All	0.837	1.000	<.001	100	view →
UCEC	OS	Tertile	III,IV	0.921	0.760	.001	94	view →
KIRP	DFS	Tertile	III,IV	0.115	0.591	.001	87	view →
HNSC	OS	Quartile	All	0.837	0.653	<.001	55	view →
LIHC	OS	Median	All	0.603	0.773	<.001	51	view →
LGG	OS	Median	All	0.743	0.870	<.001	45	view →
CESC	OS	Median	II,III,IV	0.836	0.662	.015	44	view →
ACC	DFS	Quartile	All	0.504	0.844	.001	41	view →
THYM	DFS	Quartile	II,III,IV	0.592	1.000	.004	40	view →
PAAD	OS	Quartile	All	0.461	0.727	.001	37	view →
UVM	DFS	Tertile	III,IV	0.219	0.784	.004	37	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

DCST1-AS1–KIRC (DFS)

Open the KIRC breakdown →