DCLRE1C

Across TCGA pan-cancer cohorts, DCLRE1C mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DCLRE1C data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DCLRE1C mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DCLRE1C expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where DCLRE1C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	III,IV	0.649	0.924	.029	26	view →
PDAC	OS	Median	III,IV	0.068	0.943	.038	6	view →
CCRCC	OS	Tertile	III,IV	0.442	0.963	.034	3	view →
LUAD	DFS	Median	All	0.747	0.526	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DCLRE1C–HNSC (OS)

Open the HNSC breakdown →