DCLRE1C

Across TCGA patient cohorts, DCLRE1C mutation is significantly associated with the RNA expression of many other genes, with 3,207 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCLRE1C-associated genes across cancer lineages are CCDC11P1, OR5G5P, and RNU6-937P. Each is linked with DCLRE1C in more than 2 cancer types. Because this analysis shows association rather than direction, both DCLRE1C-to-partner and partner-to-DCLRE1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC11P1 grouped by DCLRE1C-low versus DCLRE1C-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCLRE1C→partner) and Y-score (partner→DCLRE1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CCDC11P1 →	+0.024	+5.351	<.001	.002	3	3
HNSC	OR5G5P →	+0.051	+3.748	<.001	.008	3	3
UCEC	RNU6-937P →	+0.294	+1.663	.004	.002	3	3
CESC	MTND5P13 →	+0.035	+4.103	<.001	.002	3	2
CESC	RNU7-35P →	+0.283	+5.584	<.001	.001	3	2
HNSC	LINC01674 →	+0.053	+4.754	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,207 associations by consensus.

CCDC11P1 by DCLRE1C expression — HNSC

Explore this box plot interactively →