DCLRE1C

Across TCGA patient cohorts, DCLRE1C mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCLRE1C-associated genes across cancer lineages are Notch1, ATM, and EGFR_pY1068. Each is linked with DCLRE1C in more than 1 cancer types. Because this analysis shows association rather than direction, both DCLRE1C-to-partner and partner-to-DCLRE1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by DCLRE1C-low versus DCLRE1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCLRE1C→partner) and Y-score (partner→DCLRE1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.181	+2.820	<.001	.001	3	2
UCEC	ATM →	-0.501	-1.662	.001	.011	3	2
UCEC	EGFR_pY1068 →	-0.249	-2.115	.004	.016	3	1
UCEC	A-Raf_pS299 →	-0.125	-2.584	.003	.010	3	1
UCEC	FoxM1 →	+0.295	+2.392	.001	<.001	3	1
UCEC	Gab2 →	+0.478	+2.874	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Notch1 by DCLRE1C expression — UCEC

Explore this box plot interactively →