DCLRE1C

Across TCGA cell cohorts, DCLRE1C mutation is significantly associated with the RNA expression of many other genes, with 638 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DCLRE1C-associated genes across cancer lineages are PLA2G3, ANKRD54, and EIF3L. Each is linked with DCLRE1C in more than 1 cancer types. Because this analysis shows association rather than direction, both DCLRE1C-to-partner and partner-to-DCLRE1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLA2G3 grouped by DCLRE1C-low versus DCLRE1C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCLRE1C→partner) and Y-score (partner→DCLRE1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLA2G3 →	+1.150	+3.540	<.001	.002	3	1
LARGE_INTESTINE	ANKRD54 →	+0.482	+2.588	.002	.004	3	1
LARGE_INTESTINE	EIF3L →	+0.485	+3.237	.004	.003	3	1
LARGE_INTESTINE	CCDC134 →	+0.695	+3.131	.002	.008	3	1
LARGE_INTESTINE	CBY1 →	+0.581	+3.459	.001	.001	3	1
LARGE_INTESTINE	TOMM22 →	+0.540	+2.502	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 638 associations by consensus.

PLA2G3 by DCLRE1C expression — LARGE_INTESTINE

Explore this box plot interactively →