DCLRE1B

Across TCGA patient cohorts, DCLRE1B mutation is significantly associated with the RNA expression of many other genes, with 695 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCLRE1B-associated genes across cancer lineages are RNU6-275P, CDT1, and RN7SL248P. Each is linked with DCLRE1B in more than 2 cancer types. Because this analysis shows association rather than direction, both DCLRE1B-to-partner and partner-to-DCLRE1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-275P grouped by DCLRE1B-low versus DCLRE1B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCLRE1B→partner) and Y-score (partner→DCLRE1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-275P →	+0.519	+5.157	<.001	.007	3	3
UCEC	CDT1 →	+0.665	+2.202	.002	.001	3	2
UCEC	RN7SL248P →	+0.056	+3.059	<.001	.005	3	2
SKCM	VAC14 →	+0.454	+3.407	.007	.004	3	2
COAD	SRGAP3-AS1 →	+0.223	+4.790	<.001	.006	3	2
BLCA	MIR618 →	+0.178	+4.296	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 695 associations by consensus.

RNU6-275P by DCLRE1B expression — LUAD

Explore this box plot interactively →