Across TCGA patient cohorts, DCLRE1A mutation is significantly associated with the RNA expression of many other genes, with 3,168 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCLRE1A-associated genes across cancer lineages are DDIT3, IDI1, and MTND1P22. Each is linked with DCLRE1A in more than 2 cancer types. Because this analysis shows association rather than direction, both DCLRE1A-to-partner and partner-to-DCLRE1A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCLRE1A→partner) and Y-score (partner→DCLRE1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DDIT3 →	+0.532	+2.436	<.001	.001	3	3
UCEC	IDI1 →	+0.453	+1.958	.004	.002	3	3
LIHC	MTND1P22 →	+0.169	+5.186	<.001	.007	3	2
HNSC	MT-TN →	+0.341	+4.822	<.001	.006	3	2
HNSC	RNU1-101P →	+0.226	+5.763	<.001	.001	3	2
UCEC	DOC2B →	-0.818	-1.999	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,168 associations by consensus.

Exploration

DCLRE1A survival (RNA) · tumor vs normal (RNA) · all DCLRE1A data types