DCLK3

Across TCGA patient cohorts, DCLK3 mutation is significantly associated with the RNA expression of many other genes, with 4,177 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCLK3-associated genes across cancer lineages are CHCHD1, NEDD8-MDP1, and SNU13. Each is linked with DCLK3 in more than 3 cancer types. Because this analysis shows association rather than direction, both DCLK3-to-partner and partner-to-DCLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHCHD1 grouped by DCLK3-low versus DCLK3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCLK3→partner) and Y-score (partner→DCLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CHCHD1 →	+0.354	+3.214	.006	.009	3	4
UCEC	NEDD8-MDP1 →	+0.176	+1.698	<.001	.006	3	4
UCEC	SNU13 →	+0.227	+1.433	.004	.002	3	3
UCEC	FANCG →	+0.535	+1.758	<.001	<.001	3	3
UCEC	LINC01132 →	-0.393	-1.957	.002	.009	3	3
UCEC	SOCAR →	+0.276	+1.916	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,177 associations by consensus.

CHCHD1 by DCLK3 expression — LUAD

Explore this box plot interactively →