DCHS1

Across TCGA pan-cancer cohorts, DCHS1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DCHS1 data layer compared with 26 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DCHS1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DCHS1 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

PDAC, LSCC, and UCEC are the cancer types where DCHS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.675	0.965	.002	48	view →
LSCC	DFS	Median	II,III,IV	0.502	0.848	<.001	35	view →
UCEC	DFS	Median	II,III,IV	0.469	0.944	.003	20	view →
LUAD	DFS	Median	III,IV	0.485	0.995	.003	14	view →
GBM	OS	Tertile	All	0.591	0.280	.007	6	view →
CCRCC	OS	Quartile	All	1.000	0.548	.020	2	view →
HNSC	DFS	Median	All	0.984	0.921	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DCHS1–PDAC (OS)

Open the PDAC breakdown →