DCHS1

Across TCGA pan-cancer cohorts, DCHS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DCHS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DCHS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DCHS1 is over-expressed in tumor, although a few such as BLCA and KIRP show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where DCHS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DCHS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.615	<.001	10	view →
KIRC	Female	All	+1.268	<.001	9	view →
BLCA	Male	IV	−2.355	.002	8	view →
KIRP	Male	All	−1.281	<.001	7	view →
LUSC	Male	All	−1.116	<.001	6	view →
KICH	Male	All	−1.029	<.001	6	view →
LUAD	Female	All	−0.784	<.001	5	view →
BRCA	Female	All	−0.579	<.001	4	view →
LIHC	Female	All	+0.473	.013	4	view →
UCEC	All	All	−1.710	<.001	2	view →
PRAD	All	All	−0.389	.043	2	view →
CHOL	All	All	+0.990	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DCHS1–HNSC

Open the HNSC breakdown →