DCHS1

Across TCGA cell cohorts, DCHS1 mutation is significantly associated with the RNA expression of many other genes, with 1,619 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DCHS1-associated genes across cancer lineages are ZNF330, WDR48, and RAB3IP. Each is linked with DCHS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DCHS1-to-partner and partner-to-DCHS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF330 grouped by DCHS1-low versus DCHS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCHS1→partner) and Y-score (partner→DCHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF330 →	+0.491	+1.969	<.001	<.001	3	3
BLOOD_Leukemia	WDR48 →	+0.569	+3.199	.003	.007	3	3
BLOOD_Leukemia	RAB3IP →	+1.243	+3.199	.001	.007	3	3
BLOOD_Leukemia	CEP97 →	+0.885	+3.199	<.001	.007	2	4
LARGE_INTESTINE	TNRC6B →	+0.683	+1.742	<.001	<.001	3	3
LARGE_INTESTINE	GSR →	+0.597	+3.409	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,619 associations by consensus.

ZNF330 by DCHS1 expression — LARGE_INTESTINE

Explore this box plot interactively →