DCDC2

Across TCGA patient cohorts, DCDC2 mutation is significantly associated with the RNA expression of many other genes, with 1,567 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCDC2-associated genes across cancer lineages are MIR588, FAM21EP, and EEF1E1P1. Each is linked with DCDC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DCDC2-to-partner and partner-to-DCDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR588 grouped by DCDC2-low versus DCDC2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCDC2→partner) and Y-score (partner→DCDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR588 →	+0.613	+5.631	<.001	.004	3	3
SKCM	FAM21EP →	+0.183	+2.756	<.001	.002	3	2
SKCM	EEF1E1P1 →	+0.490	+3.472	.001	.002	3	2
UCEC	FANCC →	+0.357	+2.839	.008	.001	3	2
UCEC	CDK5 →	+0.342	+2.053	.004	.001	3	2
UCEC	HDGFL3 →	+0.747	+2.447	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,567 associations by consensus.

MIR588 by DCDC2 expression — LUAD

Explore this box plot interactively →