Across TCGA patient cohorts, DCC protein abundance is significantly associated with the RNA expression of many other genes, with 4,585 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DCC-associated genes across cancer lineages are ASL, ITGA7, and RNA5SP133. Each is linked with DCC in more than 1 cancer types. Because this analysis shows association rather than direction, both DCC-to-partner and partner-to-DCC results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCC→partner) and Y-score (partner→DCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ASL →	-0.426	-0.746	.009	.001	3	2
LSCC	ITGA7 →	-0.718	-0.746	<.001	.001	3	2
LSCC	RNA5SP133 →	+1.036	+0.758	<.001	<.001	3	2
GBM	FOXN3P2 →	+0.858	+0.503	.001	.003	3	2
LSCC	PAICSP4 →	+1.540	+0.746	.001	.001	3	2
LSCC	MMADHCP2 →	-1.721	-1.019	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,585 associations by consensus.

Exploration

DCC survival (RNA) · tumor vs normal (RNA) · all DCC data types