Across TCGA patient cohorts, DCAF8L1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCAF8L1-associated genes across cancer lineages are Caspase-7-cleavedD198, p38-MAPK_pT180_Y182, and PKC-delta_pS664. Each is linked with DCAF8L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DCAF8L1-to-partner and partner-to-DCAF8L1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF8L1→partner) and Y-score (partner→DCAF8L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.718	+2.019	<.001	<.001	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.283	-1.184	.015	.019	3	3
UCEC	PKC-delta_pS664 →	-0.065	-1.392	.036	.015	3	3
UCEC	ATM →	-0.490	-1.469	<.001	<.001	3	3
UCEC	A-Raf_pS299 →	-0.079	-1.353	.011	.013	3	2
UCEC	ERK2 →	+0.121	+1.847	.015	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Exploration

DCAF8L1 survival (RNA) · tumor vs normal (RNA) · all DCAF8L1 data types