Across TCGA pan-cancer cohorts, DCAF8L1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated DCAF8L1 data layer compared with 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DCAF8L1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DCAF8L1 expression acts as an unfavorable survival marker, although some lineages such as CESC and LUSC show a favorable association.

UCEC, THYM, and KICH are the cancer types where DCAF8L1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.770	0.896	<.001	88	view →
THYM	DFS	Tertile	II,III,IV	0.628	0.949	.001	81	view →
KICH	DFS	Tertile	II,III,IV	0.067	0.794	<.001	78	view →
CESC	DFS	Tertile	All	0.937	0.801	.007	54	view →
DLBC	OS	Tertile	III,IV	0.154	0.735	.010	40	view →
THCA	OS	Tertile	III,IV	0.214	0.861	.003	39	view →
LIHC	DFS	Tertile	All	0.342	0.490	.004	36	view →
KIRP	OS	Tertile	II,III,IV	0.121	0.593	.014	33	view →
LGG	DFS	Tertile	All	0.535	0.758	<.001	33	view →
LUSC	DFS	Tertile	All	0.779	0.612	.003	30	view →
SKCM	OS	Tertile	III,IV	0.641	0.844	.003	18	view →
PAAD	DFS	Tertile	All	0.658	0.176	.002	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

Exploration

Same gene, other analysis: DCAF8L1 tumor-vs-normal RNA expression · all DCAF8L1 data types