DCAF7

Across TCGA patient cohorts, DCAF7 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCAF7-associated genes across cancer lineages are A-Raf_pS299, MEK1, and EGFR_pY1068. Each is linked with DCAF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCAF7-to-partner and partner-to-DCAF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by DCAF7-low versus DCAF7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF7→partner) and Y-score (partner→DCAF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.190	-2.222	<.001	.011	3	2
UCEC	MEK1 →	+0.496	+3.807	.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.271	-2.222	.011	.011	3	1
UCEC	eIF4E →	+0.198	+3.459	.027	.005	3	1
UCEC	ERK2 →	+0.304	+2.906	<.001	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.158	-1.687	.027	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

A-Raf_pS299 by DCAF7 expression — UCEC

Explore this box plot interactively →