DCAF7

Across TCGA pan-cancer cohorts, DCAF7 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of DCAF7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DCAF7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DCAF7 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, STAD, and BLCA are the cancer types where DCAF7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DCAF7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.887	<.001	11	view →
STAD	All	III,IV	+1.170	<.001	9	view →
BLCA	Female	All	+1.015	<.001	9	view →
LIHC	Female	II,III,IV	+1.187	<.001	8	view →
KICH	Male	All	−1.130	<.001	8	view →
BRCA	All	III,IV	+0.893	<.001	6	view →
KIRC	Male	II,III,IV	−0.327	.009	6	view →
CHOL	Male	All	+2.448	<.001	5	view →
ESCA	Female	All	+1.293	.008	4	view →
LUAD	Male	II,III,IV	+0.436	.020	3	view →
COAD	Male	II,III,IV	+0.421	.003	3	view →
LUSC	All	All	+0.259	.006	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

DCAF7–HNSC

Open the HNSC breakdown →